Outcome of chromosomally normal livebirths with increased fetal nuchal translucency at 10-14 weeks' gestation.
نویسندگان
چکیده
The aim of this study was to determine the outcome of chromosomally normal livebirths with increased fetal nuchal translucency at 10-14 weeks' gestation. Clinical follow up of 89 chromosomally normal livebirths that in fetal life had a minimum nuchal translucency thickness of 3.5 mm and a comparison group of 302 infants whose fetal nuchal translucency thickness at 10-14 weeks of gestation was less than 3.5 mm was performed. Major abnormalities, mainly structural defects of the cardiovascular or skeletal systems, were found in 10.1% (nine of 89) of the group with increased translucency, compared to 2% (five of 302) in those with translucency of less than 3.5 mm (chi2=11.9, p<0.001). Delay in achievement of developmental milestones was observed in one of the infants with increased translucency and in one of the comparison group. The findings of this study show that in chromosomally normal fetuses increased nuchal translucency thickness at 10-14 weeks of gestation is a marker for fetal abnormalities including structural defects and genetic syndromes.
منابع مشابه
I-44: Increased Nuchal Translucency at 11-14 Weeks of Gestation As A Marker for Adverse Pregnancy Outcomes
Background: To evaluate the association of increased fetal nuchal translucency( NT) and adverse pregnancy outcomes. Materials and Methods: In a prospective study, 2221 women who were conceived after Assisted Conception were investigated by sonography independent of multiplicity between 11 and 13 weeks' gestation. We performed 2899 NT examinations during the study period(21 March 2010 to 21...
متن کاملCardiac defects in chromosomally normal fetuses with abnormal ductus venosus blood flow at 10-14 weeks.
OBJECTIVE To assess a possible relationship between ductus venosus blood flow abnormalities and cardiac defects in chromosomally normal fetuses with increased nuchal translucency thickness at 10-14 weeks of gestation. METHODS Ductus venosus Doppler ultrasound blood flow velocity waveforms were obtained at 10-14 weeks' gestation immediately before fetal karyotyping in 200 consecutive singleton...
متن کاملOutcome of pregnancy in chromosomally normal fetuses with increased nuchal translucency in the first trimester.
OBJECTIVES To study the outcome of chromosomally normal pregnancies with increased nuchal translucency at the 10-14-week scan. DESIGN Retrospective study of 1320 chromosomally normal singleton pregnancies with nuchal translucency of > or = 3.5 mm. In addition to fetal karyotyping these patients were managed with follow-up scans at 14-16 and 20-22 weeks, specialist fetal echocardiography and i...
متن کاملDefects and syndromes in chromosomally normal fetuses with increased nuchal translucency thickness at 10-14 weeks of gestation.
Increased fetal nuchal translucency thickness at 10-14 weeks of gestation is a common phenotypic expression of fetal chromosomal defects, structural abnormalities and genetic syndromes. This study reports on the prevalence of structural abnormalities and genetic syndromes in 4116 chromosomally normal pregnancies with increased fetal nuchal translucency thickness and reviews the relevant literat...
متن کاملThe influence of fetal sex in screening for trisomy 21 by fetal nuchal translucency, maternal serum free beta-hCG and PAPP-A at 10-14 weeks of gestation.
In a study of 2923 normal pregnancies and 203 pregnancies affected by trisomy 21 we have shown a significant difference in the median MoM of the markers: fetal nuchal translucency, maternal serum free beta-hCG and PAPP-A in the presence of a female fetus compared with a male fetus. For maternal serum free beta-hCG levels are higher by 15% if the fetus is chromosomally normal and by 11% if the f...
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 35 3 شماره
صفحات -
تاریخ انتشار 1998